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Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Drug Conjugation (ADC)

o2h Group

Ahmedabad, Gujarāt, India

Peptide Chemist:

  • Plan and execute solid-phase and solution-phase peptide synthesis (SPPS/LPPS) using automated synthesizers such as Syro and CEM Liberty Blue
  • Independently handle peptide synthesis across scales from gram to 1 kg, with troubleshooting abilities
  • Purify and characterize peptides using preparative HPLC, analytical HPLC, LC-MS, and MS
  • Operate, calibrate, and maintain lab equipment to keep synthesis workflows running smoothly
  • Maintain compliance with laboratory safety and SHE (Safety, Health & Environment) standards
  • Review relevant literature to inform synthetic strategy and troubleshooting approaches
  • Keep accurate, timely experimental records (lab notebooks, batch records, ELN entries as applicable)

High Potent APIs (HPAPI):

  • Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.
  • Execute chemical reactions, work-ups, purification and related laboratory processes.
  • Handle HPAPIs in accordance with applicable safety, containment and handling procedures.
  • Maintain accurate laboratory records, experimental data and documentation.
  • Support process development, optimization and troubleshooting activities.
  • Perform analytical sample preparation and coordinate with analytical teams as required.
  • Follow established GMP, EHS and laboratory safety requirements.
  • Support investigation and resolution of laboratory/process-related issues.
  • Where required, support chemistry activities related to ADC and highly potent payloads.
  • Work effectively with cross-functional teams including analytical and other chemistry groups.

Organic Chemist:

  • Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance
  • Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography
  • Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations
  • Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately

Scaleup Chemist:

  • Experience in process R&D, scale-up synthesis, and purification from gm to kg scale
  • Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities
  • Proficient in 1H NMR, HPLC, and LCMS interpretation
  • Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

  • Synthesis and purification of complex antibody drug conjugate (ADC) molecules
  • Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs
  • Synthesis of highly potent drug molecules – payloads
  • Purification of complex and large molecules by flash column and HPLC
  • Handling various type chemistry with different payloads
  • Interpretation and characterisation of higher molecular weight compounds

Peptide Chemist:

  • M.Sc. or M.Pharm in Organic Chemistry, Medicinal Chemistry
  • 2–4 years of hands-on experience in peptide synthesis

Principal Scientist;

  • PhD/MSc in Organic Chemistry / Medicinal Chemistry or related field.
  • Strong experience in CRO/CDMO research environment.
  • Proven team management experience with exposure to handling multiple projects.
  • Excellent communication and client-facing skills.
  • Ability to drive productivity, scientific excellence, and team development.

Organic Chemist:

  • Master’s in Organic Chemistry with 1-3 years of experience in the CRO Industry Strong organisational, project management and problem-solving skills with impeccable multi-tasking abilities.
  • Proactive, highly motivated with a "can do" attitude
  • Exceptional interpersonal skills.

Peptide/Scaleup/Antibody Drug Conjugation (ADC) Chemist:

  • Master’s in Organic Chemistry with a minimum of 2 years and a maximum of 6 years of experience in the CRO/API Industry
  • Adherence to safe practices and procedures
  • Contribution to the development of safety protocols and systems
  • Must be able to prioritize and organize work responsibilities in order to meet deadlines

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