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Open nowPosted 7 hours ago

Scientist II - Bioprocess Cell Culture Development

AbbVie2,012 open roles

Where
South San Francisco, CA, United States
Work mode
On site
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Your applicationOpen nowScientist II - Bioprocess Cell Culture DevelopmentAbbVie · South San Francisco, CA, United States

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The clock on this job

Early applications get read.

13.8% of postings close within 7 days. Measured by our own scanner across the market. AbbVie postings stay open a median of 33 days.

Share of postings closed within
  1. 2.2%1 day
  2. 4.7%3 days
  3. 13.8%7 days
  4. 22.3%14 days
  5. 37.8%30 days
  6. 59.0%60 days
This job: posted 7 hours ago

AbbVie median: 33 days open

The posting

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

The role is part of the DevSci Biologics Drug Substance group based at ABA, responsible for providing technical support to manufacturing development of novel biologics, technology transfers and bioprocess innovation projects. The candidate will be responsible for executing tasks to achieve departmental and project goals. The candidate should be experienced in standard cell culture, biochemistry, and molecular biology techniques and is expected to clearly communicate the scientific rationale, methodology and results in written and oral formats.

Key Accountabilities/Core Job Responsibilities

  • Perform routine tasks such as media/buffer preparation, thawing of cryopreserved cells, cell culture passaging, aseptic sampling and banking competently and independently to support ongoing projects in cell culture lab
  • Take routine analytical measurements for cell growth, gas-content analysis, pH, osmolality, nutrient and metabolite measurements and HPLC analysis of monoclonal antibody titers
  • Utilize technical expertise and available information to troubleshoot and resolve operational hurdles when encountered and adapt protocols as necessary
  • Propose novel scientific experiments in mammalian cell culture
  • Collaborate across CMC functions to optimize bioprocess parameters for the production of difficult-to-manufacture biologics
  • Execute high-throughput fed batch and batch experiments and perform data analysis of the same
  • Able to maintain a “can-do” attitude to complete innovative projects while being flexible in work priorities based on business needs
  • Perform tasks with rigorous attention to detail consistently. Prioritize tasks and contribute to a highly motivated and productive team with a sense of urgency and desire to meet project timelines
  • Accurately document, critically analyze/interpret data and communicate the results promptly through various electronic means
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials
  • Must be comfortable with physical activities of constant standing, walking, and sitting with arm stretching into biosafety cabinets for cell culture work and occasionally lifting 50Ibs.
  • Strong interpersonal skills to thrive in a team environment
  • Expected onsite to execute experiments in BSL II laboratory.

Qualifications

  • BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.

Experience

  • Prior experience in mammalian cell culture techniques, bioreactor operation and cell culture media preparation is a must
  • Experience in single use mammalian cell culture tools employed in bioprocess development, including but not limited to deep well plates, shake flasks, wave/rocking machines, ambr250s, stirred tank reactors from bench (<5L) to pilot scale (>50L)
  • Experience with perfusion technologies and some experience with LIMS deployment/ development is highly desirable
  • Excellent aseptic techniques and familiarity with principles of sterilization/disinfection.
  • Familiar with general troubleshooting techniques and implementation of quality controls in developmental lab
  • Experience with process development, optimization, and troubleshooting, especially with translating product quality attributes/ desired product quality profiles to relevant cell culture process conditions
  • Experience in the use of spent media analysis to inform media optimization and process development.
  • Experience in setting up high throughput experiments in both fed batch and batch modes, and comfortable with automation and manual intervention when needed.
  • Comfortable with practical considerations needed to successfully scale up conditions tested in high throughput systems to larger scales across different sites in the unit operations of cell culture cryopreservation, thaw, expansion, perfusion, fed-batch production and primary recovery.
  • Experience with the review and analysis of batch records and capable of designing experiments to address gaps between developmental processes and cGMP site capabilities where identified.
  • Excellent communication skills and experience using collaborative cloud-based technologies.
  • Knowledge of biological data collection and analysis tools (JMP, GraphPad Prism, HPLCs, Blood gas analyzers, metabolite analyzers) and computer applications such as MS Word, MS Excel and MS PowerPoint.
  • Able to maintain instrumentation, inventory and cleanliness of a developmental lab to create a safe, effective and efficient scientific working environment.

Additional Information

​Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
  • This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

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