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Open nowFirst seen 4 days ago

Scientist I, Display Technologies

BigHat Biosciences16 open roles

Pay
$120,000 – $145,000 a year
Where
San Mateo, CA
Work mode
On site
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Your applicationOpen nowScientist I, Display TechnologiesBigHat Biosciences · San Mateo, CA

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The clock on this job

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12.3% of postings close within 7 days. Measured by our own scanner across the market.

Share of postings closed within
  1. 2.1%1 day
  2. 4.5%3 days
  3. 12.3%7 days
  4. 19.3%14 days
  5. 35.6%30 days
  6. 57.8%60 days
This job: first seen 4 days ago

The posting

The role: BigHat Biosciences is seeking a curious and motivated Scientist 1 to join the Display Technologies team. This individual will contribute to BigHat’s antibody discovery and engineering efforts and help generate high-quality data to improve BigHat’s machine learning models using display technologies, working closely with senior scientists and cross-functional teams.

Key Responsibilities

  • Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models.
  • Lead in the construction and QC of phage display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
  • Execute standard phage display selections to engineer antibodies with desired therapeutic properties.
  • Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
  • Analyze selection results and contribute to discussions on next steps and future experimental design.
  • Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
  • Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components.
  • Present experimental plans and results during regular meetings with manager and science teams.
  • Effectively and regularly communicate results to key decision makers, the broader BigHat team, and to external partners.
  • Maintain thorough records using LIMS and electronic notebooks.

Skills Knowledge and Expertise

  • Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related field, with up to 2 years of industry research experience; or an M.S. in a related field with 6+ years of relevant industry research experience.
  • Experience with display technologies, including library design and selection strategies.
  • Knowledge of antibody biology and protein expression.
  • Strength in general molecular biology techniques (PCR, molecular cloning, gel electrophoresis).
  • Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms.
  • Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records.
  • Effective time management and clear written and verbal communication skills.
  • Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
  • Scientific track record and publication record.
  • Strong data analysis and interpretation skills. Experience working with agentic software tools is a plus.

Total Rewards

The salary estimated for this position is $120,000 - $145,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

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