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Open nowFirst seen 5 days ago

Scientist II, Biomolecular Characterization

BigHat Biosciences16 open roles

Pay
$145,000 – $165,000 a year
Where
San Mateo, CA
Work mode
On site
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Your applicationOpen nowScientist II, Biomolecular CharacterizationBigHat Biosciences · San Mateo, CA

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The clock on this job

Early applications get read.

12.3% of postings close within 7 days. Measured by our own scanner across the market.

Share of postings closed within
  1. 2.1%1 day
  2. 4.5%3 days
  3. 12.3%7 days
  4. 19.3%14 days
  5. 35.6%30 days
  6. 58.1%60 days
This job: first seen 5 days ago

The posting

The role: BigHat Biosciences is seeking an exceptional individual for a Scientist II or Senior Scientist I in Biomolecular Characterization* role to drive characterization of in vitro antibody-target binding behavior, develop new assay capabilities, and represent the team across BigHat’s programs.

*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.

Key Responsibilities

  • Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
  • Implement best practices for binding assay design across various bioanalytical assay formats.
  • Troubleshoot and diagnose assay issues, building foundational understanding of antibody/antigen interactions that stakeholders can act on.
  • Collaborate closely with BigHat’s science organization to accelerate hits from discovery through lead optimization and candidate nomination.
  • Effectively synthesize and communicate results and research activity to key decision makers and the broader BigHat team.
  • Partner with automation engineering, software engineering, and production teams to scale and productionize high-throughput kinetics assays.

Skills Knowledge and Expertise

  • Ph.D. 2-5 years, or M.Sc with 5+ years of independent research and development experience in an industry setting, including substantial experience with binding assays including BLI, SPR, ELISA/MSD and Flow Cytometry workflows (preferably across Carterra, Cytiva and Sartorius instrumentation).
  • Practical and theoretical fluency in bioanalytical science, biochemistry, biophysics, assay design and development (experience in both complex and buffered matrices preferred).
  • Experience with lab automation and working with automation engineers (preferred).
  • Strong data analysis and interpretation skills coupled to exceptional written, verbal, and visual communication skills.
  • Ability to educate and build consensus among diverse stakeholders regarding scientific direction.

Total Rewards

The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

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