The posting
At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.
Position Summary
Bristol Myers Squibb (BMS) seeks an innovative, results-oriented leader to serve as the Iza-Bren Medical Product Lead, Global Medical Oncology. This critical role leads the Global Medical team for Izabren (BMS-986507), a first-in-class EGFRxHER3 bispecific antibody-drug conjugate (ADC) co-developed with SystImmune, with a broad multi-tumor development program spanning breast, lung, gastrointestinal and genitourinary cancers. The MPL will lead a mission-focused team designed to accelerate clinical evidence generation, recruitment, education, and external advocacy across international markets in the rapidly evolving ADC landscape. The MPL will drive a unified strategy, high-velocity execution, and end-to-end ownership across Global Oncology, ensuring best-in-class medical engagement for Izabren as the program advances toward registration and launch. The role will report to the VP, Worldwide Medical Affairs Disease Area Head, Thoracic & H&N Cancers.
Key Responsibilities
Strategy & Direction
In close collaboration with our alliance partner, SystImmune, this role is accountable for:
- Develop and execute a unified global medical strategy for Izabren across tumor types and lines of therapy, ensuring speed, clarity, and relentless focus on program goals – in full alignment with the global & US strategy
- Lead and manage the dedicated medical Izabren teams at Global and US level, eliminating fragmentation and aligning messaging, evidence, and education across the enterprise.
- Drive rapid decision-making and execution, removing delays inherent in traditional matrix models.
Operational Leadership & Accountability
- Ensure direct accountability at international, regional, and field levels, enabling real-time progress tracking and immediate intervention.
- Optimize trial execution and site engagement across diverse markets for the global Izabren program (including Phase 2/3 and Phase 3 studies in breast cancer, lung cancer and urothelial cancer), in close collaboration with RCO & International Izabren Lead.
- Monitor the competitive landscape (including other EGFR-, HER3- and TROP2-directed ADCs, bispecifics and standard-of-care chemotherapy) and proactively adapt strategies to maintain leadership.
- Oversee resource allocation, budget management, and strategic prioritization to maximize efficiency and impact.
- Establish and monitor KPIs, dashboards, and reporting tools for continuous improvement.
- Partner with Clinical Development, Safety, Translational/Biomarker and Regulatory teams to ensure medical insights and real-world evidence needs inform the Izabren development plan and future label.
- Collaborate with the Alliance Lead and SystImmune counterparts to ensure joint medical and scientific alignment across territories.
Scientific Advocacy & External Impact
- Support building and empower a high-performing, dedicated team of regional Izabren leads and dedicated MSLs, fostering deep scientific advocacy and accelerating site activation, recruitment, and medical education, including ADC-specific topics such as toxicity management, dose optimization and biomarker strategy.
- Shape external perception and scientific leadership, leveraging early signal detection and rapid course correction; engage key opinion leaders, investigators and professional societies, and plan data dissemination at key congresses.
Cross-functional collaboration
- Partner with the Global Medical, Development, Commercial, Market Access, and Patient Advocacy teams to ensure pre-launch excellence and maximize portfolio value.
- Represent Izabren in key stakeholder & partnership meetings, including joint governance with SystImmune, driving cross-functional alignment and enterprise initiatives.
Qualifications & Experience
- Advanced degree in medicine, science, or related field (MD, PhD, PharmD; MD preferred).
- 15+ years of medical affairs, development, or commercial experience, with a strong track record in international markets.
- Pharmaceutical experience in solid tumors is a must have (breast, thoracic, GI and GU cancers); experience with ADCs, bispecific antibodies and/or Phase 3 oncology development is strongly preferred.
- Proven expertise in leading large, geographically distributed teams and driving high performance in competitive environments.
- Deep understanding of regulatory, healthcare, and cultural diversity across international markets.
- Demonstrated ability to execute strategies that deliver measurable business and patient outcomes.
- Strong cross-functional leadership and stakeholder management skills. Demonstrated ability to successfully and effectively collaborate and work across boundaries (e.g. R&D, disease mgt., marketing, external development) and building strong external relationships.
- Outstanding project management capabilities and experience in change management, leading teams through market or organizational transformation
- Ability to provide a strong voice to the global team and success in effectively communicating and influencing decisions with senior leadership and matrix team.
#LI-HYBRID
We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.
Compensation Overview:
$254,530 - $308,434
The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.
Benefits:
Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits
How We Work
Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.
Supporting People with Disabilities
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
Candidate Rights
BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page for important information about the Washington Fair Chance Act.
Data Protection
We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
If this posting is missing required information required by local law or incorrect, contact BMS at [email protected] with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.
R1608226 : Executive Director, Global Medical Oncology, Iza-Bren Medical Product Lead (MPL)
