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Open nowPosted 11 days agoWe saw it 68 min after it went up

Associate Director/Director, Biostatistics

Calico Labs21 open roles

Pay
$235,000 – $300,000 a year
Where
South San Francisco, CA
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Your applicationOpen nowAssociate Director/Director, BiostatisticsCalico Labs · South San Francisco, CA

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The clock on this job

Early applications get read.

12.3% of postings close within 7 days. Measured by our own scanner across the market. Calico Labs postings stay open a median of 62 days.

Share of postings closed within
  1. 2.1%1 day
  2. 4.5%3 days
  3. 12.3%7 days
  4. 19.3%14 days
  5. 35.6%30 days
  6. 58.1%60 days
This job: posted 11 days ago

Calico Labs median: 62 days open

The posting

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, academic and industry partners, and vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

The Associate Director or Director of Biostatistics will be responsible for providing statistical data analysis expertise and leadership to support assigned clinical programs. Calico provides a scientifically stimulating and collaborative working environment, and this role will interact with scientists from a range of disciplines including basic research, computational biology, pharmacology, PKPD and biomarker experts. We are seeking a creative and innovative statistical scientist to direct project teams towards efficient strategies for data integration across multiple platforms with the ultimate goal of deriving meaningful inferences about the human condition.

Key Responsibilities:

  • Independently lead biostatistical support for assigned therapeutic programs and clinical studies across development phases
  • Develop statistical strategies aligned with clinical development objectives and regulatory requirements
  • Collaborate with clinical and scientific teams to evaluate study design alternatives, assess risks and uncertainties, and support data-driven development decisions
  • Provide statistical input into clinical development plans, study protocols, endpoint selection, sample size considerations, and overall evidence-generation strategies
  • Develop and evaluate innovative trial designs, including adaptive designs, Bayesian approaches, and simulation-based methods, as appropriate
  • Provide statistical expertise for studies involving small sample sizes, heterogeneous patient populations, rare diseases, and limited clinical data
  • Communicate statistical concepts, assumptions, limitations, and implications clearly to cross-functional teams

Position Requirements:

  • Ph.D. in Biostatistics/Statistics or equivalent with at least 8+ years’ relevant work experiences or M.S. in Biostatistics/Statistics with at least 10+ years’ relevant experience
  • Broad and thorough understanding of statistical principles and clinical trial methodology; able to practice and implement them
  • Ability to develop innovative/creative statistical/technical solutions to complex problems
  • Leadership skills in priority evaluation, adapting to changes, conflict resolution, and effective partnership
  • Ability to work independently, exercise sound scientific judgment, and manage multiple competing priorities
  • Experience managing CROs, external statistical consultants, and statistical programming vendors
  • Experience with NDA or other major regulatory submissions
  • Excellent written and verbal communication skills, including the ability to communicate statistical concepts to non-statistical stakeholders
  • Experience supporting rare disease or other indications with small patient populations and limited clinical data is preferred
  • Experience with external control groups, natural history studies, patient registries, or systematic literature reviews is preferred
  • Must be willing to work onsite at least 4 days a week

The estimated base salary range for this role is $235,000 - $300,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

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