Skip to content
CV Rocket
Get started
How it worksThe enginePricingBlogContactSign in

Open nowPosted 17 days ago

Senior Director, Clinical Development (Medical Director)

City Therapeutics6 open roles

Pay
$255,000 – $290,000 a year
Where
Cambridge, Massachusetts, United States
Get the CV for this job

From $25 per CV, paid once. No subscription.

Your applicationOpen nowSenior Director, Clinical Development (Medical Director)City Therapeutics · Cambridge, Massachusetts, United States

  1. YouYes, apply to this one.

  2. CV RocketCV written for this posting.

  3. 25 readersRecruiter, hiring manager, skeptic. Round after round.

  4. CV RocketApplied on City Therapeutics's own form.

The reply lands in your private mailbox

3×more interviews than doing it yourself with ChatGPT.

The clock on this job

Early applications get read.

10.5% of postings close within 7 days. Measured by our own scanner across the market. City Therapeutics postings stay open a median of 12 days.

Share of postings closed within
  1. 2.1%1 day
  2. 4.3%3 days
  3. 10.5%7 days
  4. 15.9%14 days
  5. 34.1%30 days
This job: posted 17 days ago

City Therapeutics median: 12 days open

The posting

Senior Director, Clinical Development (Medical Director)

City Therapeutics is a biotechnology company pioneering next-generation RNA interference (RNAi)-based medicines. We are building a diversified pipeline of innovative therapies through advanced RNAi trigger molecule engineering and novel targeting technologies designed to expand the reach of RNAi beyond the liver. We are seeking passionate, collaborative, and courageous individuals to join our team as we work to transform scientific discoveries into meaningful medicines for patients.

Position Overview

The Senior Director, Clinical Development (Medical Director) will provide medical and scientific leadership for City Therapeutics’ clinical development programs. This individual will play a central role in shaping clinical development strategy and translating innovative RNAi science into well-designed, executable clinical programs.

The successful candidate will serve as the medical lead for one or more programs, with responsibility for clinical strategy, protocol development, study execution, data interpretation, and regulatory interactions. This individual will collaborate closely with Clinical Operations, Biometrics, Pharmacology, Toxicology, Regulatory Affairs, Translational Medicine, and other cross-functional partners.

This is an opportunity for an experienced physician-scientist to have a meaningful impact within a growing biotechnology company and help advance programs from early clinical development through key milestones, and regulatory approvals.

Key Responsibilities

  • Provide medical and scientific leadership for one or more clinical development programs.
  • Develop and execute clinical development plans aligned with overall program and corporate objectives.
  • Lead the design and development of clinical development plans, clinical study protocols, including study objectives, endpoints, eligibility criteria, dose-escalation strategies, and safety-monitoring plans.
  • Serve as the medical monitor for assigned clinical trials and provide ongoing oversight of participant safety, medical data, and emerging benefit-risk profiles.
  • Partner closely with Clinical Operations to support high-quality and timely study execution.
  • Review and interpret clinical safety, efficacy, pharmacokinetic, pharmacodynamic, and biomarker data.
  • Lead or contribute to clinical study reports, investigator brochures, regulatory submissions, informed consent documents, and other clinical and regulatory materials.
  • Present clinical strategy and program updates to executive leadership, governance committees, investigators, and external partners.
  • Support interactions with global health authorities, including the FDA and other regulatory agencies.
  • Build strong relationships with investigators, key opinion leaders, clinical research organizations, and other external partners.
  • Collaborate with Biometrics to develop statistical analysis plans and ensure the quality and integrity of clinical data.
  • Contribute medical expertise to translational, nonclinical, regulatory, and commercial planning.
  • Identify clinical risks and recommend thoughtful, practical solutions to keep programs moving forward.
  • Monitor developments in the therapeutic landscape and incorporate relevant scientific, medical, and competitive insights into clinical strategy.
  • Support due diligence, business development, and external collaboration activities, as needed.
  • Mentor and develop clinical team members and contribute to the continued growth of the Clinical Development function.
  • Foster a culture that reflects City Therapeutics’ values of Courage, Innovation, Tempo, and Yes.

Qualifications

  • MD or equivalent medical degree required.
  • Board certification or board eligibility in a relevant medical specialty strongly preferred.
  • A minimum of 6+ years of relevant clinical development experience within the biotechnology or pharmaceutical industry.
  • Experience serving as a medical monitor and providing medical leadership for clinical trials.
  • Demonstrated experience designing and executing early-stage clinical studies; experience supporting programs through later-stage development is highly desirable.
  • Strong understanding of clinical trial design, drug development, Good Clinical Practice, and global regulatory requirements.
  • Experience contributing to regulatory submissions and participating in interactions with health authorities.
  • Proven ability to analyze and communicate complex clinical and scientific information clearly and effectively.
  • Experience working within cross-functional development teams and influencing decisions in a collaborative environment.
  • Ability to operate effectively in a fast-paced, growing biotechnology company and balance strategic thinking with hands-on execution.
  • Excellent leadership, communication, organizational, and relationship-building skills.
  • Experience in RNA therapeutics, rare diseases, ophthalmology, immunology, neurology, or another relevant therapeutic area is preferred but not required.

Location: This position is based in Cambridge, Massachusetts, and requires an onsite presence five days per week.

Equal Opportunity

City Therapeutics is an equal opportunity employer. We are committed to building an inclusive workplace and consider qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, genetic information, or any other characteristic protected by applicable law.

City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment Agency inquiries or submissions will not be accepted at this time.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match. Per Year Salary Range: $255,000 to $290,000

From $25, paid onceGet the CV for this job

What happens when you press

One press. We do the rest.

  1. A CV for this posting

    Written against City Therapeutics's own wording, from every piece of relevant proof in your profile.

  2. 25 readers review it

    Recruiter, hiring manager, skeptic and more read every draft, round after round. You get the best round.

    The review screen in CV Rocket: how each CV was read, round by round.

  3. We apply on City Therapeutics's form

    Our application engine gets through the hardest forms there are. Where a question needs you, AI suggests the best answer. Don't want us applying from our IP addresses? Use our Chrome extension: we apply straight from your own browser.

    An application in CV Rocket: every answer filled in on the employer's form.

  4. Every reply, sorted

    City Therapeutics's answer lands in your private mailbox, and we classify it on arrival: interview, question, rejection.

    The CV Rocket inbox: each employer reply classified as an interview, an action or a rejection.

  5. Reply with AI

    AI helps you write the email, checks it and sends it. We show you whether the recruiter read it.

  6. The interview in your calendar

    Full integration with your calendar. The invitation goes straight in.

    An interview invitation in the CV Rocket inbox, added to the candidate's calendar.
Get the CV for this job

From $25 per CV, paid once. No subscription.

Why it works

3×

more interviews than doing it yourself with ChatGPT.

ChatGPT writes a CV and never learns what happened to it. We see every reply. For each CV we know:

  • How it was written, and how the review scored it
  • When we applied, and how long after the posting went up
  • Which posting, which company, which city
  • Who got the interview, and who heard nothing

That is how we know which CVs get called.

Get the CV for this job

From $25 per CV, paid once. No subscription.

The numbers game

More applications. More interviews.

Every application goes out with its own CV, written for that posting and paid once. Send enough of them and the law of large numbers finds you the job.

Get the CV for this job
By hand5–10
With CV Rocket100
applications a day

Nearby

Live postings like this one

Same employer first, then the same role elsewhere.

Before you press

Straight answers

Get the CV for this job

From $25 per CV, paid once. No subscription.

What if my background isn't good enough?

We make the most of the background you have. The CV uses every piece of relevant proof your profile holds, and one of the 25 readers reads your whole profile and flags what the CV left out.

Do you really apply for me?

Yes, on the employer's own form, the hardest ones included. Where a question needs you, you answer it right there and AI suggests the best answer. Don't want us applying from our IP addresses? Use our Chrome extension: we apply straight from your own browser.

Is it a subscription?

No. You pay once per CV, from $25. Every application goes out with its own CV, written for that posting.

One job. One CV.
Paid once.

Pick the posting you want. We write for it, apply for you and catch the reply.

Get the CV for this job

From $25 per CV, paid once. No subscription.