The posting
About Meridial
Meridial is a Focused Research Organisation (FRO) with a mission to bring connectomics into the living brain. We are building a platform for longitudinal, synapse-resolution mapping of functional neural circuitry in preclinical models. Our aim is to deploy this platform for translational projects and improve drug development outcomes for disorders of the central nervous system.
Meridial is a new not-for-profit FRO in the Convergent Research Ecosystem and funded by the Advanced Research and Invention Agency (ARIA).
About the role
Meridial is seeking an experimental neuroscientist to join our team as Associate Scientist – In Vivo Neuroscience.
This is a hands-on role. You will carry out neurosurgery, longitudinal two-photon imaging and optogenetic experiments in mice as part of Meridial’s programme to develop advanced 3D imaging and photostimulation technologies for functional mapping of neural circuits.
We are looking for a scientist with strong practical and experimental skills. You should already have substantial hands-on experience with mouse neurosurgery and in vivo two-photon imaging and be motivated to develop these skills further.
You will join a small Experimental Team that will grow over the coming year, and will be able to contribute to the development of protocols and workflows from an early stage. You will report to the Director of Experimental Research and will receive hands-on training and mentoring from more senior scientists in the team. You will also work closely with engineers and computational researchers across Meridial.
Key Responsibilities
- Perform survival neurosurgery in mice, including stereotaxic viral injections, cranial-window implantation and preparation of animals for chronic imaging and manipulation.
- Carry out high-quality in vivo two-photon imaging, including longitudinal imaging of the same animals over weeks to months.
- Run optogenetic experiments to interrogate and manipulate neural circuits.
- Support the implementation of viral and transgenic strategies for functional imaging, circuit manipulation and anatomical investigation.
- Support animal colony management, working with senior team members and animal facility staff, including tracking breeding and experimental requirements.
- Monitor preparation quality and animal welfare throughout longitudinal studies and help identify and resolve technical problems with more senior scientists.
- Maintain accurate and comprehensive records of experimental procedures and outcomes.
- Follow the team’s surgical and experimental protocols and contribute to their development, optimisation and documentation as SOPs.
- Help test, evaluate and optimise new surgical, imaging and experimental approaches, including systematic evaluation of variables that affect preparation quality, reproducibility and long-term stability.
- Help test and improve microscopes, behavioural apparatus and other experimental systems in collaboration with the Engineering Team.
- Work with the Computational Team to support data acquisition, data-quality assessment and analysis, and to make sure data and metadata meet the standards needed for open sharing.
- Contribute to experimental planning, interpretation and discussion within the Experimental Team.
- Communicate results, technical problems and observations clearly to colleagues across disciplines.
- Share technical expertise and good experimental practice with other team members.
- Uphold high standards of experimental rigour, reproducibility and animal welfare.
Essential Qualifications and Experience
- Degree in neuroscience, neurobiology, physiology, neuroengineering or a related discipline, or equivalent research experience.
- 3+ years’ hands-on experience with in vivo neuroscience experiments in mice.
- Demonstrated experience of survival stereotaxic surgery in mice, including intracranial viral injections and cranial-window implantation for chronic imaging.
- Substantial hands-on experience with in vivo two-photon microscopy and the acquisition of functional neural data.
- Familiarity with viral-vector and genetic approaches commonly used to study neural circuits.
- Ability to recognise experimental problems, troubleshoot procedures and contribute to method optimisation.
- Understanding of appropriate experimental controls and rigorous experimental design.
- Strong organisational skills and careful experimental record-keeping.
- Ability to work effectively as part of a multidisciplinary team and to respond constructively to scientific and technical guidance.
- If you do not already hold a UK Home Office Personal Licence covering the relevant procedures, willingness to complete the required training before starting the role. Meridial will cover the costs of the required training and licence application. Candidates trained under another national regulatory framework are very welcome.
- Strong commitment to animal welfare, the 3Rs and rigorous experimental practice.
Desirable Qualifications and Experience
- Any of the following would be particularly valuable:
- 5+ years’ practical experience with in vivo neuroscience experiments
- Longitudinal two-photon imaging of the same neural populations, cellular compartments or synaptic structures over weeks or months.
- In vivo imaging of dendrites, axons, boutons or other subcellular structures.
- Optogenetic experiments, including their design and optimisation and the combination of optical stimulation with functional neural measurements.
- All-optical circuit interrogation, such as two-photon optogenetics or holographic photostimulation.
- GRIN-lens, prism or other specialised chronic optical preparations.
- AAV, rabies-virus or other viral-vector strategies for neural labelling, imaging, manipulation or tracing, including monosynaptic rabies tracing or other transsynaptic circuit-mapping approaches.
- Histology, immunohistochemistry and confocal or fluorescence microscopy.
- In vivo or ex vivo intracellular electrophysiology, including whole-cell or targeted patch-clamp recording.
- Spatial transcriptomics, single-cell spatial profiling or related molecular approaches.
- Head-fixed behavioural experiments combined with neural imaging or manipulation.
- A current UK Home Office Personal Licence covering the relevant procedures.
- Microscope alignment, optical troubleshooting or work with custom two-photon imaging systems.
- Quantitative assessment of experimental quality and development of quality-control procedures.
- Working knowledge of Python and/or MATLAB for experimental control, data-quality assessment or analysis.
- Preparing experimental data for open sharing.
Physical Demands
- Fine motor skills for operating computers and office/lab equipment
- Ability to move light-to-moderately heavy items (typical lab supplies/equipment); may include occasional lifting/carrying with appropriate equipment (e.g., carts/dollies)
The Person We Are Looking For
Position Type / Schedule
- Start date: around March 2027.
- Full-time, 37.5 hours/week.
- Laboratory based in London, with an on-site presence of 4–5 days per week due to the experimental nature of the role.
- Longitudinal experiments and post-operative animal care will at times require work outside normal hours, including occasional weekends. This will be planned in advance and shared across the team as it grows.
Additional Information
- Application materials: CV/resume + cover letter
- 2 references will be requested during interviews
- Generous Benefits will be communicated in interviews
- For exceptional candidates, Meridial will consider visa sponsorship and relocation support.
We are an Equal Employment Opportunity employer and do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable law or company policy. We strive for a diverse, healthy and safe workplace and strictly prohibit harassment of any kind.
