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Open nowPosted 46 hours ago

Promovendus

EURES job mobility portal314,718 open roles

Where
Arnhem/Nijmegen, Netherlands
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Your applicationOpen nowPromovendusEURES job mobility portal · Arnhem/Nijmegen, Netherlands

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  2. CV RocketCV written for this posting.

  3. 25 readersRecruiter, hiring manager, skeptic. Round after round.

  4. CV RocketApplied on EURES job mobility portal's own form.

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The clock on this job

Early applications get read.

7.8% of postings close within 7 days. Measured by our own scanner across the market.

Share of postings closed within
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  2. 3.4%3 days
  3. 7.8%7 days
  4. 14.3%14 days
  5. 33.7%30 days
This job: posted 46 hours ago

The posting

Promovendus 'TRAnslational Framework For Innovation in Cerebral amyloid angiopathy'. Radboud UMC · Nijmegen Over de vacature - 32 - 36 uur per week - CV + Motivatiebrief + Extra upload mogelijkheden - Salaris: €3.724-€5.867 per month - Solliciteer voor 23 oktober 2026 Cerebrale amyloïd angiopathie (CAA) is een veel voorkomende hersenaandoening, die gekenmerkt wordt door afzetting van amyloïd-β (Aβ) in arteriolen en capillairen in de hersenen. CAA is een belangrijke oorzaak van hersenbloedingen, maar draagt ook in belangrijke mate bij aan dementie, waaronder de ziekte van Alzheimer. Bij Alzheimer-patiënten vormt CAA het substraat voor potentieel ernstige bijwerkingen ('ARIA') van anti-amyloïde immunotherapieën. Naast de sporadische vorm van CAA bestaan er inflammatoire subtypen (CAA-gerelateerde ontsteking; CAA-ri en ARIA) waarvan de onderliggende mechanismen nog onvoldoende bekend zijn. Ondanks de hoge prevalentie en klinische impact bestaan er voor aandoeningen binnen het CAA-spectrum onvoldoende sensitieve diagnostische methoden. De huidige diagnostische criteria op basis van MRI hebben beperkte sensitiviteit, vooral in een vroeg stadium en bij de inflammatoire subtypen. Daarnaast ontbreekt in de huidige criteria integratie met moleculaire biomarkers die de onderliggende biologie van de cerebrale vaten weerspiegelen. Het doel van het internationale TRAFFIC consortium netwerk is om deze onderliggende moleculaire processen in kaart te brengen en te vertalen naar klinisch bruikbare biomarkers, waarmee de kloof tussen mechanistisch onderzoek en diagnostiek op patiëntniveau wordt overbrugd. In het consortium wordt er gewerkt vanuit experimentele diermodellen, hersenweefsel en moderne analyse technieken om biomarkers voor het CAA spectrum in kaart te brengen. Biomarkers worden getoetst in grote klinische cohorten op hun diagnostische waarde. Op basis hiervan worden nieuwe diagnostische modellen gecreëerd en vertaald in klinische rich...

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