Skip to content
CV Rocket
Get started
How it worksThe enginePricingBlogContactSign in

Open nowPosted 33 hours agoWe saw it 97 min after it went up

Senior Research Associate / Associate Scientist, Nonclinical

Flagship Pioneering, Inc.93 open roles

Pay
$81,000 – $126,500 a year
Where
Cambridge, MA USA
Get the CV for this job

From $25 per CV, paid once. No subscription.

Your applicationOpen nowSenior Research Associate / Associate Scientist, NonclinicalFlagship Pioneering, Inc. · Cambridge, MA USA

  1. YouYes, apply to this one.

  2. CV RocketCV written for this posting.

  3. 25 readersRecruiter, hiring manager, skeptic. Round after round.

  4. CV RocketApplied on Flagship Pioneering, Inc.'s own form.

The reply lands in your private mailbox

3×more interviews than doing it yourself with ChatGPT.

The clock on this job

Early applications get read.

13.6% of postings close within 7 days. Measured by our own scanner across the market. Flagship Pioneering, Inc. postings stay open a median of 34 days.

Share of postings closed within
  1. 2.3%1 day
  2. 4.7%3 days
  3. 13.6%7 days
  4. 21.9%14 days
  5. 36.9%30 days
  6. 59.0%60 days
This job: posted 33 hours ago

Flagship Pioneering, Inc. median: 34 days open

The posting

Alltrna is looking for a hands-on scientist to join our Nonclinical team, where we test how well our engineered tRNAs work across a range of preclinical disease models. The ideal candidate is a strong cell and molecular biologist who is detail-oriented, intellectually curious, and energized by being part of a collaborative, fast-paced, small-company environment.

Working closely with the Nonclinical team, this individual will select, develop, and optimize the assays we use to measure tRNA activity and efficacy. These include cell-based assays in primary cells and hepatocyte models to the RNA and protein readouts that support in vivo studies. The candidate will design, execute and analyze data that support platform expansion and drive early-stage programs into clinical development. This role will have opportunities to propose new ideas, collaborate with groups across the company and participate in broader data reviews and decision-making.

We are hiring at the Senior Research Associate or Associate Scientist level, depending on experience. We are looking for someone who takes ownership of their experiments, works carefully and efficiently, and can troubleshoot technical challenges and adapt to changing priorities while maintaining scientific rigor.

Key Responsibilities:

  • Design, optimize, qualify, validate, and implement cell-based assays that support early-stage discovery efforts, selection of new indications, and advancement of lead candidates into IND-enabling studies
  • Execute in vitro assays and process in vitro and in vivo samples to support nonclinical studies, following approved protocols and SOPs
  • Conduct biochemical assays to support the development of clinical and nonclinical biomarkers
  • Document experiments accurately and promptly in the electronic laboratory notebook (ELN), ensuring data integrity, traceability, and complete records
  • Perform mammalian cell culture, cell line characterization, and cell line development, including DNA/RNA delivery by transfection, transduction, electroporation, or LNP-based methods
  • Perform molecular and cellular assays, including PCR/qPCR, Western blot/Jess, immunostaining, luciferase/bioluminescence assays, and flow cytometry
  • Analyze, interpret, and clearly present experimental results to the Nonclinical and Research Leadership Teams
  • Contribute to SOP development and manage reagents and inventory to support consistent, reproducible experiments
  • Manage multiple studies in parallel, adapt to shifting priorities, and meet study timelines
  • Collaborate with team members and cross-functional partners to share results and communicate progress or issues promptly

Key Qualifications:

  • BS or MS in biology, biochemistry, pharmacology, or a related field
  • Minimum BS with 4+ years or MS with 2+ years of hands-on laboratory experience in academia, biotechnology, or the pharmaceutical industry; more experience required at Associate scientist level.
  • Strong experience in mammalian cell culture, including primary cells and cell lines; stem cell experience is a plus
  • Experience with cell line characterization and development, including growth curves, kill curves, clonal expansion, and mycoplasma testing
  • Hands-on experience with DNA/RNA delivery methods, such as transfection, lentiviral or AAV transduction, electroporation, or LNP-based delivery
  • Experience with molecular and cellular techniques, including:
  • PCR, qPCR/RT-qPCR, and molecular cloning
  • Western blot/Jess
  • Immunocytochemistry (ICC), immunohistochemistry (IHC), and immunofluorescence (IF)
  • Luciferase/bioluminescence assays
  • Flow cytometry
  • Experience designing and optimizing cell-based assays for drug discovery
  • Ability to analyze data using appropriate statistical methods and clearly communicate experimental results
  • Strong attention to detail and ability to follow established procedures accurately
  • Ability to manage multiple tasks, adapt to changing priorities, and work effectively in a fast-paced biotech environment
  • Strong communication, organization, and teamwork skills

Preferred Qualifications

  • Experience working with RNA therapeutics, including mRNA, siRNA, or antisense oligonucleotides
  • Experience culturing primary human hepatocytes, induced pluripotent stem cells (iPSCs), or iPSC-derived hepatocyte-like cells
  • Experience with high-content imaging, IncuCyte, or confocal microscopy
  • Experience with genetic manipulation using CRISPR or other genome-editing approaches
  • Experience developing disease-specific cellular assays
  • Experience with ligand-binding assays and multiplex immunoassay platforms, such as MSD or Luminex, for cytokine, immunogenicity, or biomarker analysis

About Alltrna

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affects approximately 10% of people with a rare genetic disease. Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics.

For more information, visit www.alltrna.com

The salary range for this role is $81,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].

From $25, paid onceGet the CV for this job

What happens when you press

One press. We do the rest.

  1. A CV for this posting

    Written against Flagship Pioneering, Inc.'s own wording, from every piece of relevant proof in your profile.

  2. 25 readers review it

    Recruiter, hiring manager, skeptic and more read every draft, round after round. You get the best round.

    The review screen in CV Rocket: how each CV was read, round by round.

  3. We apply on Flagship Pioneering, Inc.'s form

    Our application engine gets through the hardest forms there are. Where a question needs you, AI suggests the best answer. Don't want us applying from our IP addresses? Use our Chrome extension: we apply straight from your own browser.

    An application in CV Rocket: every answer filled in on the employer's form.

  4. Every reply, sorted

    Flagship Pioneering, Inc.'s answer lands in your private mailbox, and we classify it on arrival: interview, question, rejection.

    The CV Rocket inbox: each employer reply classified as an interview, an action or a rejection.

  5. Reply with AI

    AI helps you write the email, checks it and sends it. We show you whether the recruiter read it.

  6. The interview in your calendar

    Full integration with your calendar. The invitation goes straight in.

    An interview invitation in the CV Rocket inbox, added to the candidate's calendar.
Get the CV for this job

From $25 per CV, paid once. No subscription.

Why it works

3×

more interviews than doing it yourself with ChatGPT.

ChatGPT writes a CV and never learns what happened to it. We see every reply. For each CV we know:

  • How it was written, and how the review scored it
  • When we applied, and how long after the posting went up
  • Which posting, which company, which city
  • Who got the interview, and who heard nothing

That is how we know which CVs get called.

Get the CV for this job

From $25 per CV, paid once. No subscription.

The numbers game

More applications. More interviews.

Every application goes out with its own CV, written for that posting and paid once. Send enough of them and the law of large numbers finds you the job.

Get the CV for this job
By hand5–10
With CV Rocket100
applications a day

Nearby

Live postings like this one

Same employer first, then the same role elsewhere.

Before you press

Straight answers

Get the CV for this job

From $25 per CV, paid once. No subscription.

What if my background isn't good enough?

We make the most of the background you have. The CV uses every piece of relevant proof your profile holds, and one of the 25 readers reads your whole profile and flags what the CV left out.

Do you really apply for me?

Yes, on the employer's own form, the hardest ones included. Where a question needs you, you answer it right there and AI suggests the best answer. Don't want us applying from our IP addresses? Use our Chrome extension: we apply straight from your own browser.

Is it a subscription?

No. You pay once per CV, from $25. Every application goes out with its own CV, written for that posting.

One job. One CV.
Paid once.

Pick the posting you want. We write for it, apply for you and catch the reply.

Get the CV for this job

From $25 per CV, paid once. No subscription.