The posting
Description
The Senior Scientist provides scientific and technical leadership in the management, design and execution of a clinical research program. With a broad range of skills and experience, this individual is a critical component of the Principle Investigators laboratory, demonstrating a capacity for collaboration and innovation with consistently high productivity.
Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplant (HCT) and prevents this curative therapy from wider application in cancer patients. Gastrointestinal (GI) GVHD is the target organ that is most resistant to steroid treatment and acute GVHD in the GI tract accounts for the vast majority non-relapse mortality. This research project seeks to elucidate its basic biology and develop new laboratory strategies to predict its long-term outcomes. It explores the regeneration of crypts by Intestinal Stem Cells (ISCs) during GVHD, using in vitro model pathways that control inflammatory cell death.
Responsibilities
- Designs and conducts complex clinical research studies requiring the determination and evaluation of alternative methods, diagnosis and treatment.
- Dissects euthanized mice for organoids. Performs organoid establishment and passage after exacting murine organoids from the duodenum and the colon. Flushes with cold phosphate-buffered saline (PBS), opens longitudinally, and then thoroughly washes to remove fecal content.
- Analyzes organoids in single-cell suspensions. Stains cell with live/dead violet followed by anti-mouse epithelial cell adhesion molecule. Utilizes BD LSRFortessa flow cytometer to analyze epithelial and immune cell populations.
- Analyzes and interprets laboratory data from research studies including usage of Western Blots where snap-frozen organoids are lysed in Triton buffer on ice and are then centrifuged. Quantifies data using ImageJ software. Creates data visualization and statistical analysis using GraphPad Prism.
- Explores subject area and defines scope and selection of problems for investigation through conceptually related studies.
- Develops hypotheses to be tested and methodology for evaluating results.
- Communicates research results to the scientific community via published papers
- Coordinates seminars and discussions for dissemination of knowledge and results of research in order to develop new diagnosis or treatment.
- Develops new proposals for research and obtain support for new and/ or continuing research activities.
- Makes decisions and recommendations that have a major impact on extensive scientific research activities.
- Supervises graduate/ medical students and trainees.
- Performs other related duties.
Qualifications
- Ph.D in sciences or related field
- Minimum five years of experience with scientific investigation.
- Must have demonstrated outstanding achievement in a field of research
- Must have contributed to a number of peer-reviewed publications, inventions or the like, at least some of which have had a major impact on advancing the field or discipline.
- Prior experience successfully securing external grant funding is highly desirable.
Employer Description
Strength through Unity and Inclusion
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.
About the Mount Sinai Health System:
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
Equal Opportunity Employer
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58661 - $131588.09 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
