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Open nowPosted 13 hours ago

Associate Director / Director of Product Management, Signatera Hematologic Oncology (Heme)

Natera223 open roles

Pay
$180,300 – $230,900 a year
Where
US Remote
Work mode
Remote
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Your applicationOpen nowAssociate Director / Director of Product Management, Signatera Hematologic Oncology (Heme)Natera · US Remote

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The clock on this job

Early applications get read.

13.3% of postings close within 7 days. Measured by our own scanner across the market. Natera postings stay open a median of 29 days.

Share of postings closed within
  1. 2.1%1 day
  2. 4.6%3 days
  3. 13.3%7 days
  4. 21.3%14 days
  5. 35.7%30 days
  6. 59.1%60 days
This job: posted 13 hours ago

Natera median: 29 days open

The posting

Position Summary:

Natera is a global leader in cell-free DNA testing, focused on changing the management of disease in reproductive health, oncology, and organ transplantation. Signatera is a personalized, tumor-informed test for molecular residual disease (MRD) assessment and surveillance monitoring in patients previously diagnosed with cancer.

The Associate Director / Director of Product Management, Signatera Heme will own the product strategy and roadmap for Signatera in hematologic malignancies, starting with multiple myeloma and lymphomas. This person will work in a highly matrixed environment with the Foresight BU, R&D, Lab Operations, Software Engineering, Medical Affairs, Marketing, Business Development, and Regulatory. The role combines product management, market entry as a laboratory developed test (LDT), evidence generation, analytics, and clinical trial product support, including trials run under IUO and IVD pathways.

Primary Responsibilities:

  • Develop and execute the Signatera product roadmap for hematologic malignancies, beginning with multiple myeloma and lymphomas (for example, DLBCL, follicular, mantle cell, and Hodgkin lymphoma) and extending to additional heme indications.
  • Lead market entry planning for Signatera in heme as a laboratory developed test (LDT), including clinical validation requirements, CLIA and state requirements, market access/reimbursement and payer considerations, and launch readiness with Lab Operations, Regulatory, Medical, commercial and Marketing.
  • Define product requirements for blood-based malignancies with R&D, Lab Operations, and Software Engineering, including assay, sample type, workflow, and reporting needs.
  • Lead product support for clinical trials using Signatera in heme, including IUO use in studies with pharma and academic partners, and the path toward IVD and regulated use.
  • Partner with Regulatory, Clinical, and Business Development on trial start-up, study requirements, and pharma and companion diagnostic opportunities.
  • Build product performance metrics and dashboards. Analyze test volume, adoption, ordering patterns, turnaround time, and retention. Use the results to prioritize improvements.
  • Partner with Medical Affairs and Clinical on evidence generation strategy and execution. Areas of collaboration include identifying clinical gaps, designing studies, working with investigators and trial partners, and planning publications and congress presentations.
  • Guide product development for Signatera Genome in heme, including whole genome sequencing technology, phased variants, and structural variants. Work with R&D and Bioinformatics to define how these features improve tumor tracking and MRD sensitivity in heme malignancies.
  • Conduct Voice of Customer interviews, market research, and competitive and market intelligence in hematologic oncology.
  • Engage with key opinion leaders, advisory boards, and congresses (for example, ASH, EHA, and ASCO). Gather insights to guide product decisions.
  • Work with Marketing on product positioning, launch plans, pricing, and key collateral.
  • Build business cases and financial models to support product initiatives.
  • Present strategy, progress, and data-driven recommendations to executive leadership.
  • Performs other duties as assigned.

Qualifications:

  • Bachelor’s degree in life sciences, statistics, engineering, or a related field. Advanced degree (MS, PhD, or MBA) preferred.
  • 5+ years (7+ preferred) of experience in product management, product marketing, or market analytics at a diagnostics, biotech, or pharmaceutical company.
  • Hematologic oncology experience is strongly preferred, especially multiple myeloma and lymphoma.
  • Working knowledge of oncology molecular testing, next-generation sequencing (NGS), and biomarkers, including NGS bioinformatic workflows (e.g., variant calling, filtering, and interpretation) and genomic data analysis. MRD experience preferred.
  • Experience with data analysis. SQL, Snowflake, or similar tools preferred.
  • Familiarity with a high complexity molecular laboratory, including cfDNA or plasma workflows, is a plus.
  • In depth knowledge of whole genome sequencing and variant types, including structural variants, single nucleotide variants, and phased variants, is preferred.
  • Experience with clinical trials. Experience in IUO and IVD regulated environments is required.
  • Experience bringing a molecular test to market as an LDT, including clinical validation and laboratory requirements.
  • Experience designing or supporting clinical evidence generation, such as clinical validation studies, retrospective studies, or prospective trials.
  • Prior KOL engagement and external customer facing experience preferred.
  • 30-40% travel for advisory boards, congresses, and customer meetings.

Knowledge, Skill, and Abilities:

Technical

  • Understanding of MRD in multiple myeloma and lymphomas, including how blood-based MRD testing fits withing current bone marrow and imaging-based MRD assessment paradigms.
  • Understanding of how somatic variants are detected in whole genome sequencing and how they support MRD tracking in heme tumors.
  • Understanding of LDT market entry requirements and the evidence needed for clinical adoption and payer coverage.
  • Ability to translate customer and clinical needs into clear product requirements.
  • Strong analytical skills. Able to build metrics, interpret data, and present findings.
  • Basic financial modeling skills.
  • Proficiency with MS Excel, Word, and PowerPoint.

Behavioral

  • Ability to lead without authority and influence cross-functional teams.
  • Strong written and oral communication skills and ability to function effectively in a highly matrixed cross functional environment.
  • Ability to explain complex topics simply (biomarkers, multiple indications, regulatory pathways).
  • Strong customer focus, including building relationships with thought leaders.
  • Strong organization and time management. Able to manage several projects at once and meet tight deadlines.
  • Flexibility between fast development and quality standards.
  • Clear written and verbal communication with senior leadership.

PHYSICAL DEMANDS & WORK ENVIRONMENT

Duties are typically performed in a [remote home office / hybrid office] setting. This position requires the ability to use a computer keyboard, communicate over the telephone and computer, and read printed material. Duties may require working outside normal working hours (evenings and weekends) at times. While the position may be based anywhere in the United States, availability during Pacific time hours is required and site based presence in San Carlos CA, Boulder CO, or Austin TX is preferred.

Travel required for this position: 30-40% (advisory boards, congresses, customer meetings).

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$180,300—$230,900 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information: - BBB announcement on job scams - FBI Cyber Crime resource page

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