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Open nowPosted 5 days ago

Staff Scientist

PanTarg

Where
Denmark
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Your applicationOpen nowStaff ScientistPanTarg · Denmark

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This job: posted 5 days ago

The posting

PanTarg is a Danish biotechnology company developing novel anti-cancer therapies in the form of antibody-drug conjugates (ADCs) for the treatment of aggressive cancers with high unmet medical need.

Our work is based on more than 30 years of research conducted at Rigshospitalet and University of Copenhagen, and our vision is to enable novel treatment options for cancer patients via a novel first-in-class approach to targeted therapy.

We are currently incubated at the BioInnovation Institute (BII), a Copenhagen-based incubation hub for biotech startups in Europe. Here, we are currently progressing through preclinical development, aiming to reach a stage of clinical testing within a few years.

The position

We are looking for a Staff Scientist to join our team on site at BII. We are looking for a candidate with robust experimental experience with both in vivo xenograft studies as well as in vitro methods such as assay development, ELISA, flow cytometry and dose-response studies of drug candidates in cell culture. The selected candidate will generate data that supports our early translational activities, our non-clinical safety studies, and business decisions.

Qualifications

In vivo experience – Xenograft models

  • Robust (5+ years) of hands-on experience with xenograft models of cancer, including CDX, PDX and orthotopic models.
  • Strong practical experience with standard in vivo procedures, including I.V. injection via tail vein (must-have), blood collection, tissue collection, necropsy and general animal monitoring. Experience in preparing drug formulations and dosing solutions for administration, including appropriate handling and preparation of injectable drug candidates, is also required.
  • Experience in the context of pharmacokinetic (PK) studies will be considered an advantage.
  • Experience in planning, conducting and monitoring in vivo studies, as well as managing external CROs conducting such studies.

In vitro experience – Laboratory assays and protein characterization

  • 5+ years of hands-on laboratory experience, with a strong focus on assay development, optimization and protocol troubleshooting.
  • Experience with relevant assays and techniques, including ELISA, flow cytometry (multicolor panels) and dose-response studies of drug candidates in standard cell culture models.
  • Good understanding of antibody biology and properties, as well as protein characterization, antibody concentration determination and purity assessment using techniques such as UV-Vis spectrophotometry, SDS-PAGE and Western blotting.
  • Experience with additional laboratory methods and assay platforms is also relevant.

Data analysis and reporting

  • Experience in analyzing, interpreting and presenting experimental data from both in vivo and in vitro studies.
  • Ability to perform relevant statistical analyses, generate graphs and visualize experimental results.
  • Experience in preparing clear and structured experimental reports and presenting study results and conclusions.

Other qualifications

  • The optimal candidate will have obtained a PhD degree and have at least 4-5 years of experience from either pharma or biotech, or as a post doc.
  • Good scientific project management and communications skills, and the ability to clearly and precisely present data to a professional audience.
  • Good interpersonal skills, and the ability to thrive in a startup environment where flexibility and a can-do attitude is part of everyday work life.
  • Fluent in the English language, written as well as spoken.
  • On-site presence at the BioInnovation Institute in Copenhagen will be required.

General information and how to apply

  • You will be reporting to the Chief Scientific Officer.
  • The position is full time.
  • Interviews will be conducted on an ongoing basis, and the selected candidate will start as soon as possible.
  • Application takes place via the application system here at LinkedIn.
  • Please provide and combine, in a single file (PDF), a one-page CV, as well as a short, motivated application letter (also one page), summarizing your relevant experience, key responsibilities in previous roles, and motivation for applying for the position. Note that the application system only allows uploading of a single document.
  • Questions about the open position should be addressed to the e-mail address [email protected]

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