The posting
Role Summary:
The Senior Director, Oncology Portfolio Strategy is a senior strategic leader responsible for shaping the long-term Oncology portfolio strategy and investment agenda. The Oncology portfolio represents a significant opportunity to advance Pfizer's ambition to deliver breakthrough therapies for patients with cancer and related serious conditions. This role will contribute to that ambition by leading the development of commercial portfolio strategies across tumor types, modalities, and innovation platforms, enabling disciplined investment decisions that maximize patient impact and portfolio value.
The position serves as a key thought partner to Oncology leadership, translating scientific, clinical, commercial, competitive, and financial insights into enterprise-level recommendations. Working across Research, Development, Commercial, Medical, Access, Business Development, and Finance, the Senior Director drives portfolio prioritization, resource allocation, external innovation assessments, and long-range strategic planning to ensure Pfizer's Oncology portfolio remains differentiated and competitive. This role will also help evolve portfolio management frameworks, governance processes, and decision-support capabilities to strengthen strategic decision-making across the Oncology organization.
The Senior Director will partner closely with R&D, Medical Affairs, Global Access Strategy & Pricing (GASP), Global Commercial Analytics (GCA), Competitive Intelligence, Regulatory, Business Development, US, Global and International Commercial / Marketing leadership. The Senior Director will help advance disciplined trade-off decisions, long-range portfolio thinking, and AI-enabled ways of working that support patient impact and enterprise value realization for the Oncology portfolio.
Responsibilities:
Portfolio Strategy & Long-Range Planning:
- Lead development and evolution of the Oncology portfolio strategy, identifying the highest-value opportunities across tumor types, mechanisms, modalities, and therapeutic platforms.
- Develop long-range portfolio scenarios and strategic roadmaps that inform future investment priorities and portfolio evolution.
- Assess portfolio strengths, gaps, risks, and opportunities to support proactive decision-making and resource allocation.
- Drive portfolio-level strategic trade-off discussions, balancing scientific opportunity, probability of success, patient impact, and commercial value.
- Translate complex scientific and market dynamics into actionable portfolio recommendations for senior leadership.
Investment Strategy & Governance:
- Serve as a strategic advisor to Oncology leadership on portfolio prioritization and capital allocation decisions.
- Lead development of portfolio recommendations for governance committees and enterprise decision-making forums.
- Establish and maintain frameworks that improve consistency, rigor, and transparency in portfolio evaluations.
- Drive enterprise discussions on investment prioritization, development sequencing, indication expansion, and lifecycle optimization.
- Support to Enterprise / PMT request for assessments / valuations.
- Support critical portfolio reviews and recommendation development for senior executive stakeholders.
Enterprise Insight Generation:
- Integrate scientific, clinical, epidemiologic, access, policy, patient, competitive, and commercial insights into cohesive portfolio strategies.
- Monitor emerging oncology trends and evolving standards of care to identify potential portfolio implications.
- Evaluate disruptive technologies, novel modalities, and future treatment paradigms that may alter portfolio priorities.
- Develop strategic perspectives on the future evolution of the oncology landscape and the resulting implications for Pfizer.
- Lead Commercial Dashboards / reports / scenario planning to inform senior leadership.
Strategic Leadership & Organizational Impact:
- Partner across Research, Development, Medical, Commercial, Access, Portfolio Decision Analysis, Regulatory, Finance, and Business Development to drive alignment around portfolio priorities.
- Lead highly visible, cross-functional strategic initiatives with enterprise-wide impact.
- Shape and advance portfolio management capabilities, methodologies, and AI-enabled decision-support approaches.
- Serve as a trusted strategic thought partner and influencer across the Oncology organization.
- Mentor and develop colleagues while fostering a culture of strategic thinking, innovation, and analytical rigor.
Cross-Functional Leadership and Governance:
- Lead and influence complex, matrixed cross-functional teams across Research, Development, Medical, Commercial, Access, Portfolio Decision Analysis, Regulatory, Finance, and Business Development.
- Partner with senior Oncology leaders to ensure a strong commercial voice is incorporated into portfolio, early development, investment, and lifecycle decisions.
- Support preparation for governance forums, portfolio reviews, strategy discussions, development decision points, and investment prioritization meetings.
- Build trusted working relationships across global, regional, and local stakeholders to align on strategic choices, assumptions, implications, and execution priorities.
- Provide senior leadership to ensure heme strategies are integrated across disease-area, asset, launch, access, and regional considerations.
Matrix Team Leadership and Talent Development:
- Set clear priorities, accountabilities, and ways of working, ensuring high-quality strategic outputs and strong partnership with cross-functional stakeholders.
- Create an environment of accountability, collaboration, learning, and enterprise thinking, while modeling Pfizer values and fostering a high-performing team culture.
- Develop team capability in scientific and competitive landscape assessment, early commercial strategy, portfolio decision support, business case development, and executive communication.
- Provide guidance, feedback, and development opportunities to cross functional team.
AI-Enabled Ways of Working:
- Use AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, portfolio analysis, and strategy workstream efficiency.
- Apply AI-augmented approaches to accelerate analysis, identify patterns across complex data sources, and improve quality and consistency of strategic outputs.
- Champion responsible, compliant AI-enabled ways of working across heme early commercial strategy, portfolio assessment, and decision-support processes.
- Build team capability and confidence in AI-enabled strategy development, synthesis, and commercial decision support.
- Stay current on emerging tools and practices that can strengthen portfolio strategy, commercial development, and launch-readiness decision-making.
Basic Qualifications:
- Bachelor's degree required
- 12+ years of successful, progressive experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, business development, strategy consulting, corporate strategy, or related fields.
- Experience in Oncology.
- Demonstrated experience leading enterprise-level strategic initiatives and influencing significant investment decisions.
- Experience leading highly visible, cross-functional initiatives in complex matrix organizations.
- Proven ability to synthesize scientific, clinical, commercial, competitive, and financial information to support portfolio prioritization and capital allocation decisions.
- Strong strategic, analytical, and financial acumen, including experience evaluating risk, uncertainty, and value creation across multiple opportunities.
- Track record of influencing senior leadership and driving alignment among diverse stakeholder groups.
- Excellent communication, facilitation, organizational, and executive-ready storytelling skills.
Preferred Qualifications:
- Advanced degree in business, life sciences, medicine, pharmacy, public health, or related field preferred.
- Experience developing long-range portfolio strategies covering multiple disease areas, modalities, or therapeutic platforms.
- Experience supporting governance bodies, investment committees, or enterprise portfolio reviews.
- Demonstrated success shaping portfolio prioritization frameworks, resource allocation decisions, and strategic trade-off discussions.
- Experience assessing both internal pipeline opportunities and external innovation opportunities, including licensing, partnerships, and acquisitions.
- Deep understanding of portfolio management principles, valuation methodologies, forecasting, and investment decision-making.
- Deep understanding of the oncology ecosystem, including evolving standards of care, emerging science, competitive dynamics, and future market evolution.
- Experience evaluating opportunities across multiple tumor types and mechanisms rather than a single disease area.
- Ability to connect scientific innovation with portfolio-level value creation and strategic differentiation.
- Experience advising senior executives on complex strategic decisions with significant business impact.
- Demonstrated ability to lead through ambiguity and navigate competing stakeholder priorities.
- Experience establishing new strategic frameworks, processes, or capabilities that improve organizational decision-making.
- Comfort operating in an AI-enabled or AI-augmented environment; experience using AI tools to support strategy, synthesis, scenario planning, or analysis is a plus.
- Ability to thrive in ambiguity, make decisions and recommendations with incomplete information, and lead teams through evolving portfolio priorities.
- Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Work Location Assignment: Hybrid
Other Job Details:
Last day to apply: October 20, 2026
The annual base salary for this position ranges from $214,900.00 to $358,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.


Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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