The posting
Goal
We are seeking a highly motivated Postdoctoral Fellow to advance the discovery, mechanistic qualification, and clinical translation of endogenous biomarkers of cytochrome P450 (CYP) enzyme activities. Reliable assessment of CYP inhibition and induction is important for predicting clinical drug-drug interactions, but available endogenous biomarkers remain limited by biological variability, insufficient sensitivity, and incomplete mechanistic understanding. The successful candidate will lead experimental and analytical research toward establishing a mechanistically qualified biomarker panel by integrating clinical biomarker analysis, multiplex LC-MS/MS bioanalysis, mechanistic ADME studies, pharmacokinetic data analysis, and physiologically based pharmacokinetic modeling.
What You Will Achieve
In this role, you will:
- Evaluate candidate biomarkers across diverse clinical datasets and investigate biological and mechanistic factors that influence their performance.
- Determine how metabolic enzymes, membrane transporters, renal and biliary clearance, and enterohepatic processes influence biomarker disposition.
- Identify and mechanistically explain variability or discordance among candidate biomarkers.
- Develop a quantitative relationship between endogenous biomarker responses and changes in the pharmacokinetics of sensitive CYP substrates.
- Advance the scientific foundation for incorporating endogenous biomarkers into clinical DDI assessment and drug-development decision-making.
- Develop expertise across bioanalysis, mechanistic ADME, clinical pharmacology, quantitative modeling, and scientific communication.
Here Is What You Need (Minimum Requirements):
- PhD in pharmaceutical sciences, pharmacology, pharmacokinetics, drug metabolism, analytical chemistry, biochemistry, biomedical sciences, chemical biology, quantitative pharmacology, or a closely related discipline.
- Strong scientific training in at least one area directly relevant to the project, such as bioanalysis, metabolomics, drug metabolism, mechanistic ADME, enzymology, membrane transporter science, pharmacokinetics, or quantitative pharmacology, with demonstrated ability or interest in working across multiple scientific disciplines.
- Relevant hands-on research experience in bioanalysis, in vitro drug metabolism, membrane transporter research, or another experimental area directly related to mechanistic ADME.
- Demonstrated experience designing, conducting, analyzing, and interpreting hypothesis-driven research.
- Ability to critically analyze complex experimental or quantitative datasets and draw scientifically supported conclusions.
- Evidence of scientific productivity through peer-reviewed publications, submitted manuscripts, conference presentations, or comparable research contributions.
- Strong written and verbal communication skills, including the ability to present research findings clearly and contribute to scientific manuscripts.
- Ability to work effectively and collaboratively in a multidisciplinary research environment.
- Strong organizational skills, attention to experimental detail, and the ability to manage multiple research activities.
Bonus Points If You Have (Preferred Requirements):
- Strong hands-on experience with quantitative LC-MS/MS, including assay development, optimization, and analysis of small molecules, metabolites, or endogenous biomarkers in biological matrices.
- Hands-on experience with in vitro ADME assays, with preference for experience using recombinant CYP enzymes, human liver microsomes, or hepatocytes; relevant transporter-assay experience is also highly valued.
- Strong knowledge of pharmacokinetic and drug-drug interaction principles, including clearance, exposure, concentration-time relationships, and interpretation of inhibition or induction effects.
- Familiarity with PBPK modeling, population pharmacokinetics, pharmacometrics, or other mechanistic modeling approaches.
- Experience using scientific data-analysis software, such as R, Python, MATLAB, or comparable tools.
- Demonstrated ability to integrate bioanalytical, mechanistic, and quantitative data and communicate conclusions clearly.
- Strong interest in multidisciplinary translational research and in developing expertise beyond the candidate’s primary area of training.
Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development
