The posting
Job Description
A 3-year (5+3) or 4-year (4+4) PhD position in organic and supramolecular chemistry is available for a highly motivated candidate at the Department of Physics, Chemistry and Pharmacy (FKF) at the University of Southern Denmark. The position is funded by a DFF-Research Project 1 grant from the Independent Research Fund Denmark – Natural Sciences and is available from January 1, 2027, or as soon as possible thereafter.
The project focuses on the design and synthesis of electroactive molecular machines capable of converting electrically controlled molecular motion into mechanical force. In particular, the project will investigate whether redox-induced shuttling in mechanically interlocked molecules can be used to trigger the cleavage of covalent bonds and thereby enable controlled cargo release.
Project Background
The aim of this project is to develop electrically responsive molecular machines capable of converting redox-induced molecular motion into covalent cargo release.
Specifically, the project will focus on the design and synthesis of [2]rotaxanes incorporating a redox-active monopyrrolotetrathiafulvalene (MPTTF) unit, a cyclobis(paraquat-p-phenylene) (CBPQT4+) macrocycle, and a furan-based unit linked to a cargo molecule through a Diels–Alder adduct.
Upon electrochemical oxidation of the MPTTF unit, the CBPQT4+ macrocycle is expected to undergo shuttling along the molecular axle. The central hypothesis is that this redox-induced motion can generate sufficient mechanical force to promote a retro-Diels–Alder reaction, resulting in the release of the covalently attached cargo molecule. A key objective is to establish a direct mechanistic relationship between redox-induced macrocycle movement, the generation of mechanical force, and the cleavage of a covalent bond.
The project will involve extensive synthetic organic chemistry, the preparation and characterization of mechanically interlocked molecules, and investigations of their electrochemical and mechanical properties using techniques such as NMR spectroscopy, mass spectrometry, UV–vis spectroscopy, and cyclic voltammetry.
By combining synthetic, spectroscopic, and electrochemical studies, the project aims to establish whether electrically driven molecular motion can be harnessed to induce covalent bond cleavage. The results are expected to contribute to the fundamental understanding of force transduction in artificial molecular machines and may provide a foundation for future applications in controlled molecular release.
Qualifications
The ideal candidate holds a Master's degree (5+3 programme) or a Bachelor's degree (4+4 programme) in chemistry or a closely related field, preferably with a strong background in synthetic organic chemistry.
The successful candidate should have:
- Extensive practical experience in synthetic organic chemistry.
- A strong interest in supramolecular chemistry and molecular machines.
- Experience with standard analytical and spectroscopic characterization techniques.
- The ability to work independently as well as collaboratively in a research environment.
- Good communication skills and proficiency in written and spoken English.
Previous experience in supramolecular chemistry, mechanically interlocked molecules, or tetrathiafulvalene chemistry would be an advantage but is not a prerequisite.
The successful candidate will also be expected to contribute to the supervision of Bachelor's and Master's students working on research projects within the group.
For further information about the position please contact Professor Jan O. Jeppesen ([email protected]).
To learn more about the PhD programme at the Department of Physics, Chemistry and Pharmacy, read more here.
Natural Science Research – Interdisciplinary Strength The Department of Physics, Chemistry and Pharmacy is one of four departments at the Faculty of Science, SDU and is located in Odense. At the Department, we contribute to solving some of society’s greatest challenges within energy, environment, health, and sustainability. We succeed because we build bridges between disciplines and transcend traditional boundaries. Our interdisciplinary mindset is not only a fundamental condition, but also our strength. And it is a strength that ensures our research and education are recognized both nationally and internationally.
Our vision is to create and apply knowledge across the natural sciences. We are unique in housing research within physics, chemistry, and pharmacy under one department, which provides excellent opportunities to explore the intersections between these disciplines. Read more about our vision here.
Application, salary etc.
The successful applicant will be employed in accordance with the agreement on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary (only available in Danish) and taxation.
Salary is determined in accordance with the applicable collective agreement and based on objective and gender-neutral criteria, including the content of the position, responsibilities, and qualification requirements.
As an applicant, you are entitled to information about the starting salary and salary range for the position. This information will be provided during the recruitment process.
SDU does not collect information on applicants’ previous salary.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period.(the 5+3 programme).
Further information about the PhD programme at the Faculty of Science can be found at the homepage of the University.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be in English and made in the form of a Declaration of Interest including the following:
- A letter of motivation (maximum two pages), including a description of the applicant's research interests and motivation for applying for the position.
- A curriculum vitae, including a list of publications (if applicable).
- Copies of relevant diplomas and academic transcripts, including grades. if Master's diploma has not yet been received, please include statement from your supervisor.
- The names and complete contact details (phone numbers and e-mail) of at least two referees details for at least 2 referees who can vouch for your skills.
Shortlisting may be used in the assessment process. Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
Applications should be sent electronically via the link "Apply now". The faculty expects applicants to read the information "How to apply: FAQ" before applying. Please note that the application documents should be in pdf-format and attached as three documents: motivation letter, CV and the remaining documents.
We recommend that as an international applicant you take the time to visit Work in Denmark where you will find information and facts about moving to, working and living in Denmark, as well as the International Staff Office at SDU.
If you experience technical problems, please contact [email protected]
We recommend that as an international applicant you take the time to visit Work in Denmark where you will find information and facts about moving to, working and living in Denmark, as well as the International Staff Office at SDU.
About SDU
The University of Southern Denmark was established to create value for and with society. Whether our contributions come in the form of excellent research, innovative solutions, education or learning, we must make a positive difference to society and contribute to a sustainable future. We do this by cultivating talents and creating the best environments for research and learning. It is therefore crucial that SDU retains, develops and recruits talent. At the same time, we need to ensure consistently high quality in all our activities – and we can only do that with the right people. The University’s researchers, lecturers, students, managers and technical/administrative staff are the foundation of our success.
