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Open nowPosted yesterday

SENIOR SCIENTIST, BIOANALYTICS

Sutro Biopharma5 open roles

Where
South San Francisco, CA, United States
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Your applicationOpen nowSENIOR SCIENTIST, BIOANALYTICSSutro Biopharma · South San Francisco, CA, United States

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This job: posted yesterday

The posting

SENIOR SCIENTIST, BIOANALYTICS

Position Overview

Sutro Biopharma is seeking a highly motivated and experienced Senior Bioanalytical Scientist to join its Preclinical Development team in South San Francisco, CA. The successful candidate will lead the design and execution of bioanalytical strategies for discovery, preclinical, and early clinical development programs. S/he will be responsible for developing and qualifying bioanalytical methods for small molecules and antibody-drug conjugates (ADCs), including drug-to-antibody ratio (DAR) assessment, and transferring these methods to CROs to enable preclinical and clinical studies. This role requires deep expertise in LC-MS/MS-based bioanalysis and a proven track record of independently driving complex programs in a fast-paced, collaborative environment.

Responsibilities

  • Lead and implement bioanalytical (BA) strategies to address key scientific questions across discovery, preclinical, and early clinical programs
  • Develop stage-appropriate LC-MS/MS-based bioanalytical methods to quantify antibodies, ADCs, and small molecules in various biological matrices
  • Transfer bioanalytical methods to CROs and serve as the primary scientific lead overseeing external studies
  • Manage CRO relationships to ensure high-quality data delivery, adherence to timelines, and alignment with program goals
  • Assess in vitro and in vivo drug-to-antibody ratio (DAR) stability using high-resolution mass spectrometry
  • Analyze, interpret, and clearly communicate DMPK/BA data to internal project teams, senior leadership, and external collaborators
  • Author high-quality DMPK/BA reports to support IND submissions, regulatory filings, patent applications, and publications
  • Mentor and supervise junior bioanalytical scientists as needed
  • Serve as a functional representative on cross-functional project teams, including partnered programs
  • Contribute to the development of organizational processes, infrastructure, and resource planning, including capital equipment and budget considerations

Qualifications:

  • Ph.D. in PK/ADME, analytical chemistry, or a related field with 7+ years of relevant industry experience (biologics and small molecules)
  • Exceptional candidates without a Ph.D. with 12+ years of relevant experience may be considered
  • Proven track record of developing and optimizing quantitative bioanalytical methods for small molecules, biologics, and conjugates
  • Strong expertise in LC-MS instrumentation, including triple quadrupole and high-resolution mass spectrometry
  • Hands-on experience with ADC bioanalysis, including DAR characterization
  • Demonstrated ability to independently establish new experimental protocols using novel methods or techniques
  • Experience with ligand-binding assays is a plus
  • Experience developing automated sample handling and assay workflows is preferred
  • Familiarity with PK analysis and interpretation
  • Working knowledge of regulatory guidance (FDA, ICH) relevant to bioanalytical and DMPK studies
  • Experience with LIMS and common analytical/data processing software
  • Demonstrated ability to author technical reports supporting regulatory filings, patents, and publications
  • Excellent communication skills and ability to thrive in a collaborative, cross-functional environment

Sound exciting? Apply today and join our team!

Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.

As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.

We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies.

The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma’s California based locations will be $174,000 - $208,000 (not including bonus, equity, and benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.

About Sutro Biopharma

Sutro Biopharma, Inc. is advancing a next-generation antibody-drug conjugate (ADC) platform designed to deliver single- and dual-payload ADCs that enable meaningful breakthroughs for patients with cancer. By fully optimizing the antibody, linker, and payload, Sutro’s cell-free platform produces ADCs that are engineered to improve drug exposure, reduce side effects, and expand the range of treatable tumor types. With unique capabilities in dual-payload ADCs, Sutro aims to overcome treatment resistance and redefine what’s possible in cancer therapy. The Company’s pipeline of single- and dual-payload ADCs targets large oncology markets with limited treatment options and significant need for improved therapies.

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