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Open nowPosted 85 days ago

Principal Scientist- Integrated Drug Discovery

Yashraj Biotechnology Limited23 open roles

Where
Navi Mumbai
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Your applicationOpen nowPrincipal Scientist- Integrated Drug DiscoveryYashraj Biotechnology Limited · Navi Mumbai

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The clock on this job

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11.5% of postings close within 7 days. Measured by our own scanner across the market.

Share of postings closed within
  1. 2.1%1 day
  2. 4.4%3 days
  3. 11.5%7 days
  4. 18.1%14 days
  5. 35.6%30 days
  6. 44.6%60 days
This job: posted 85 days ago

The posting

  • To own YBL Vision, Values and Mission.
  • Reprogramming somatic cells to establish disease and healthy and disease iPSC lines, ensuring reproducibility and quality compliance throughout the process.
  • Differentiating iPSC lines to target derivatives (e.g., cardiac, neural, skin cell types) using lineage-specific protocols
  • Developing and validating NAM models which are Fit for Purpose and Context of Use (CoU).
  • End-to-end characterization of differentiated cells including lineage marker expression by immunofluorescence, flow cytometry, and RNA/protein-based assays.
  • Development and validation of CIVMs– Complex in vitro models and validation e.g. organoid, organ on chip.
  • Knock in knock out studies using CRISPR technology.
  • Documentation and maintenance of detailed records for all characterization assays to ensure traceability and regulatory compliance.
  • Drive the QMS process as per the ISO 9001 and 13485 compliance.
  • Set scientific vision and drive strategic research direction for iPSC disease modeling, differentiation technologies, and translational applications.
  • Lead and mentor cross-functional teams in designing, optimizing, and scaling iPSC manufacturing and differentiation processes using cutting-edge techniques.
  • Oversee process development from early-stage research to non-cGMP-ready manufacturing, ensuring scalability, compliance, and technology transfer.
  • Guide project portfolio prioritization, establish milestones, and proactively manage timelines, budgets, and resources for high-impact internal and external programs
  • Function as a key scientific reference, providing expert advice, troubleshooting, and decision-making support for junior and senior scientists across multiple active projects.
  • Represent scientific programs at regulatory meetings, conferences, and strategic partner engagements, shaping industry standards and responding to agency inquiries.
  • Champion innovation in assay development, process engineering, and automation for iPSC platforms, with a focus on next-generation manufacturing solutions.
  • Take accountability for global technical alignment, troubleshooting complex scientific and operational challenges across company sites or partner collaborations.
  • Foster a culture of continuous improvement and high data integrity, driving quality control, safety standards, and compliance with regulatory guidelines.
  • Responsible for ALCOA+++ and GMP compliance practices.
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