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Open nowPosted 106 days ago

Scientist - Antibody Conjugation

Yashraj Biotechnology Limited16 open roles

Where
Navi Mumbai
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Your applicationOpen nowScientist - Antibody ConjugationYashraj Biotechnology Limited · Navi Mumbai

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The clock on this job

Early applications get read.

12.3% of postings close within 7 days. Measured by our own scanner across the market. Yashraj Biotechnology Limited postings stay open a median of 1 days.

Share of postings closed within
  1. 2.1%1 day
  2. 4.5%3 days
  3. 12.3%7 days
  4. 19.3%14 days
  5. 35.6%30 days
  6. 58.1%60 days
This job: posted 106 days ago

Yashraj Biotechnology Limited median: 1 days open

The posting

Yashraj Biotech is seeking a highly motivated Scientist with 4–5 years of industrial experience in antibody bioconjugation, immunoassay development, and diagnostic reagent development. The candidate will work in the development and optimization of antibody-latex conjugates for immunoturbidimetric assays while collaborating with multidisciplinary R&D and Quality teams to deliver robust diagnostic products.

Key Responsibilities

  • Design, execute, and optimize antibody purification, characterization, and bioconjugation workflows. Develop EDC/NHS-based covalent conjugation strategies for latex and nanoparticle-based diagnostic reagents. Optimize antibody loading, blocking conditions, coupling chemistry, and conjugate stability. Develop and optimize immunoturbidimetric assays (ITA) Design and execute DOE-based optimization studies for conjugation efficiency and assay performance. Evaluate analytical performance including sensitivity, specificity, linearity, precision, dynamic range, and robustness. Troubleshoot conjugation, assay performance, and reagent stability issues. Maintain accurate experimental documentation, SOPs, technical reports, and development records in compliance with GLP. Mentor junior scientists, trainees, and interns in laboratory techniques and experimental planning. Participate in technology transfer activities and support manufacturing scale-up of developed reagents.

Cross-Functional Responsibilities

  • Collaborate with Polyclonal and Monoclonal Antibody R&D teams for antibody selection and characterization. Work closely with Quality Control (QC) during analytical validation and product performance evaluation. Coordinate with Quality Assurance (QA) to ensure compliance with documentation, change control, and regulatory requirements. Support Manufacturing in process optimization and troubleshooting during scale-up. Participate in product development meetings, technical reviews, and root-cause investigations. Contribute to continuous process improvement and new technology implementation.

Required Technical Skills

Antibody & Protein Sciences

  • Strong understanding of monoclonal, polyclonal, artificial polyclonal antibodies. Knowledge of antibody structure, affinity, avidity, stability, and antigen-antibody interaction kinetics. Experience handling native and recombinant antigens and antibodies. Hands-on experience in antibody purification using ammonium sulphate precipitation, dialysis, ultrafiltration, and related techniques. Understanding of protein stability and conjugate characterization.

Bioconjugation

  • Hands-on industrial experience in EDC/NHS chemistry, Maleimide–Thiol Chemistry, Glutaraldehyde Coupling Expertise in antibody immobilization onto latex beads , nanoparticles Understanding of surface chemistry, functional group activation, antibody orientation, and conjugation efficiency Experience in optimization of conjugation parameters for improved assay performance

Latex/Nanoparticle Diagnostics

  • Experience developing latex-based diagnostic reagents. Understanding of particle size selection, surface modification, colloidal stability, blocking strategies, and storage stability. Knowledge of reagent formulation and long-term stability assessment.

Immunoassays

  • Hands-on experience with Immunoturbidimetric Assays (ITA) Working knowledge of ELISA and CLIA platforms Experience in assay optimization, calibration curve generation, cut-off determination, and analytical validation

Analytical Techniques

Experience with:

  • Immunoturbidometry UV-Visible Spectrophotometry Downstream processing of polyclonal antibodies Dynamic Light Scattering (DLS) Zeta potential analyser Dialysis and ultrafiltration Statistical analysis of assay performance

Laboratory Practices

  • Excellent laboratory skills including precision pipetting and sample handling. Experience working under GLP/GMP environments. Knowledge of laboratory safety, contamination control, and documentation practices.

Desired Competencies

  • Strong experimental design and scientific problem-solving skills. Excellent troubleshooting and analytical thinking. Ability to independently manage multiple R&D projects. Strong written and verbal scientific communication. Experience mentoring junior team members. Good organizational and project management skills. Ability to work effectively in cross-functional teams.
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