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Open nowPosted 13 days agoWe saw it 69 min after it went up

Scientist, Reagent Quality Control

nautilus biotechnology10 open roles

Pay
$96,000 – $142,000 a year
Where
San Carlos
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Your applicationOpen nowScientist, Reagent Quality Controlnautilus biotechnology · San Carlos
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The clock on this job

Early applications get read.

9.0% of postings close within 7 days. Measured by our own scanner across the market. nautilus biotechnology postings stay open a median of 5 days.

Share of postings closed within
  1. 1.8%1 day
  2. 3.9%3 days
  3. 9.0%7 days
  4. 15.5%14 days
  5. 34.0%30 days
This job: posted 13 days ago

nautilus biotechnology median: 5 days open

The posting

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring for a Scientist, Reagent Quality Control to join our growing team. This role will lead the development, optimization, and execution of QC methods for incoming inspection and in-house reagent production. You will lead the development and execution of analytical methods — FPLC, HPLC, gel electrophoresis, and plate-based assays, and functional sequencing assays to support reagent QC. You will own the batch records and documentation for all QC performed and drive continuous improvement of these documents and methods. You will also develop and optimize release criteria and specifications, analyze data across multiple lots, and lead troubleshooting, nonconformance (NC), CAPA, and root-cause investigations to closure. This position reports to the Director of Operations and is located in San Carlos, CA.

Responsibilities

- Develop, optimize, and execute FPLC, HPLC and plate-based assays to support reagent QC and new reagent validation.

- Lead lot release, stability testing, and qualification of critical reagents.

- Develop and define QC release criteria, specifications, and acceptance limits for reagents, partnering with R&D and Operations.

- Lead nonconformance (NC) and out-of-specification (OOS) investigations with structured root-cause analysis, and drive corrective and preventive actions (CAPA) to closure.

- Support deviation handling, change control, and method qualification/validation in line with the quality system.

- Design and develop new analytical methods, drive optimization of existing QC methods, and mentor junior team members.

- Ensure data quality and integrity by establishing best practices and maintaining a high standard of organization and detail.

- Maintain and organize work areas, including hoods, benches, chemical storage, and waste disposal. Support calibration and maintenance of laboratory instruments.

- Problem-solving: Independently troubleshoot and perform root-cause analysis on failed assays or equipment malfunctions, and design the experiments needed to resolve them.

- Author and own Standard Operating Procedures, Test Methods, Development Reports, and other documentation.

Required Qualifications

- PhD in Chemistry, Biochemistry, or a related field with 2+ years of relevant industry experience; or an MS with 4+ years of relevant industry experience.

- Experience with HPLC and/or FPLC (AKTA), gel electrophoresis, BLI, and plate-based assays.

- Hands-on experience developing QC release criteria, specifications, and acceptance limits, and executing method qualification/validation.

- Working knowledge of quality-system processes — nonconformance (NC), CAPA, root-cause analysis, OOS investigations, and change control.

- Ability to work independently, lead projects, and collaborate as part of a team.

- Desire to work in a highly cross-functional, fast-paced environment.

- Willingness to learn and grow within a transformative company.

Nautilus Team Culture

· We are determined to do whatever it takes to get our platform into the hands of researchers who will use it to upend the status quo in basic research and healthcare.

· We work on cross functional teams, wear many hats, take risks to work through uncertainty, enjoy working collaboratively on challenging problems, and celebrate one another’s victories.

· We go above and beyond, but also strive to provide a supportive atmosphere of colleagues who are willing to lend a helping hand and make working at Nautilus not only fulfilling in its end goals, but enjoyable on a day-to-day basis.

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