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Open nowPosted 8 hours ago

Senior Computational and Experimental Scientist

Clera281 open roles

Where
New York
Work mode
Remote
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Your applicationOpen nowSenior Computational and Experimental ScientistClera · New York

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The clock on this job

Early applications get read.

8.2% of postings close within 7 days. Measured by our own scanner across the market. Clera postings stay open a median of 4 days.

Share of postings closed within
  1. 1.8%1 day
  2. 3.6%3 days
  3. 8.2%7 days
  4. 15.2%14 days
  5. 34.0%30 days
This job: posted 8 hours ago

Clera median: 4 days open

The posting

ABOUT THE ROLE

Join a lean team at an early-stage AI-driven biotech company, working across computational protein design, experimental biology, and scientific software. You will help close the design-make-test-model loop, using experimental results to improve models and deliver more useful sequences.

WHAT YOU'LL DO

- Refine discrete diffusion, protein language, and structure prediction models, including model architectures and constrained redesign workflows.

- Operate and improve a scientific inference platform, and analyze user behavior, usage patterns, and churn.

- Write, debug, and deploy protocols for liquid-handling robots and manage screening instrumentation.

- Run BLI or SPR assays end-to-end, from assay design and sample preparation through kinetic fitting and quality control.

- Diagnose experimental and computational failure modes, including mass transport, nonspecific binding, aggregation, and poor referencing.

- Design sequences, synthesize or express them, measure kinetics, update models, and iterate on improved candidates.

- Support scientific users and customer adoption with accurate, personalized outreach and an understanding of biotech buying processes.

WHAT WE'RE LOOKING FOR

- At least 2 years building or operating protein design, protein language, or structure prediction systems in a design-make-test workflow.

- At least 3 years in biotech or life sciences software go-to-market, solutions engineering, or customer success, including converting free users to paid offerings.

- Hands-on experience writing production methods for Hamilton, Tecan, Opentrons, or equivalent liquid handlers.

- Hands-on experience designing BLI or SPR assays, fitting kinetic curves, and troubleshooting assay results.

- Practical experience with tools such as ESM, ProtT5, RFdiffusion, BindCraft, or equivalents, plus Python or similar scripting for automation and data analysis.

- Biology, biochemistry, or life sciences knowledge, including protein structure, receptor biology, and scoring functions.

- Experience with scientific software users, biotech sales cycles, peptide design, protein engineering, or drug discovery is valuable.

COMPENSATION & BENEFITS

Consulting engagement compensation is $3,000 to $5,000 per month. Full-time conversion offers a base salary of $80,000 to $200,000 annually, depending on experience, plus equity. Visa sponsorship is not available.

LOCATION

Hybrid, based in New York, United States, with increased on-site presence as internal screening operations launch.

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