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Open nowPosted 262 days ago

AIDD-抗体研发科学家

evopointbio/73901724 open roles

Where
Shanghai, Chinese Mainland
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Your applicationOpen nowAIDD-抗体研发科学家evopointbio/739017 · Shanghai, Chinese Mainland

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The clock on this job

Early applications get read.

11.5% of postings close within 7 days. Measured by our own scanner across the market.

Share of postings closed within
  1. 2.1%1 day
  2. 4.4%3 days
  3. 11.5%7 days
  4. 18.1%14 days
  5. 35.6%30 days
  6. 44.6%60 days
This job: posted 262 days ago

The posting

1.结构预测与优化 o应用前沿AI模型（如AlphaFold, RoseTTAFold）预测抗体-抗原及其他蛋白复合物结构并针对项目需求优化分析流程 o使用分子动力学模拟（GROMACS/AMBER）优化大分子稳定性与结合界面 2.抗体开发支持 o主导抗体人源化、亲和力成熟及可开发性的计算设计 o构建结构-功能关系模型指导实验团队突变设计 3.跨部门协作 o为内部抗体平台、三元复合物平台开发部门提供可行动的结构优化方案 o与结构生物部门协作，推进实验结构与预测结构的交叉验证 o参与项目里程碑评审，推动候选分子进入临床开发

必需条件： •教育背景： o计算生物学/结构生物学/生物物理或相关领域博士，1-3年经验 •项目经验： o至少1个抗体开发项目的深度参与（从计算到实验验证） o蛋白复合物结构预测/优化项目经验 •技术能力： o掌握深度学习框架（PyTorch/TensorFlow）模型开发与部署 o掌握分子动力学模拟（GROMACS/AMBER）与结果分析 o加分项：能熟练使用Schrödinger Suite进行抗体设计相关工作

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