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Open nowPosted 8 days ago

Head of In Vitro Pharmacology

Proteros Biostructures GmbH11 open roles

Where
Munich
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Your applicationOpen nowHead of In Vitro PharmacologyProteros Biostructures GmbH · Munich

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9.0% of postings close within 7 days. Measured by our own scanner across the market.

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  2. 3.9%3 days
  3. 9.0%7 days
  4. 15.5%14 days
  5. 34.1%30 days
This job: posted 8 days ago

The posting

Your mission

  • Establish all in vitro pharmacology capabilities and processes required for integrated drug discovery programs.
  • Define and lead the required design, execution, and analysis of cell-based assays to support hit identification, hit-to-lead, and lead optimization campaigns.
  • Select, engineer, and characterize disease-relevant cell lines, including stable and transient transfection models.
  • Provide strategic input into target selection and validation.
  • Design strategies for high-throughput screening campaigns using advanced assay technologies (NanoBRET, NanoBiT, TR-FRET, AlphaScreen, luminescence, reporter gene activation, FLIPR and others).
  • Apply molecular and cellular biology techniques (e.g., Western blot, qPCR, gene editing, siRNA knockdown, biomarker assays) to evaluate compound activity, efficacy, mechanism of action and pathway engagement.
  • Ensure robust experimental design, reproducibility, and data quality while meeting project timelines.
  • Lead and mentor a team of research associates and scientists to achieve operational and scientific excellence.
  • Collaborate and communicate effectively within cross-functional drug discovery teams, including medicinal chemistry, biophysics, structural biology, protein sciences, and computational chemistry.
  • Align scope, timelines and decision points for support of med chem optimization, and generate high-quality in vitro pharmacology data packages to support IND-enabling activities and candidate nomination decisions.
  • Present scientific capabilities and findings to internal stakeholders and external partners.
  • Lead implementation of automation, liquid handling systems, and high-throughput assay processing to enhance team productivity and scalability.

Your profile

Required

  • PhD in Cellular Biology, Pharmacology, Chemical Biology or a related discipline.
  • 10+ years of industry experience in in vitro pharmacology within a small molecule drug discovery setting (biotech or pharmaceutical).
  • Extensive expertise in cellular and molecular biology techniques.
  • Proven track record of contributing to the progression of small molecule drug candidates from hit to candidate nomination.
  • Hands-on experience with assay development for potency, efficacy, target engagement, selectivity, and mechanism of action of small molecules.
  • Proficiency in mammalian cell culture (including establishing and maintaining transient and stable cell lines).
  • Long-standing experience with liquid handling systems, automation, and high-throughput assay execution.
  • Strong skills in data analysis, interpretation, and scientific communication.
  • Demonstrated ability to manage multiple projects in a fast-paced, dynamic research environment.
  • Strong leadership skills with experience managing research associates and scientists.
  • Excellent organizational, written, and oral communication skills.
  • Experience in one or more key disease areas, including oncology, immunology, neuroscience, or metabolic diseases.

Preferred

  • Familiarity with CRO operating environment, including multi-client project management, resource planning, and client-facing scientific communication.
  • Experience with targeted protein degradation modalities (PROTACs, molecular glues, bifunctional degraders).
  • Knowledge of DMPK interface: protein binding, metabolic stability, and their impact on in vitro assay interpretation.
  • Experience operating within an IND-enabling or GLP-compliant environment.

Why us?

  • An entrepreneurial scientific environment at a world-leading structure-based drug discovery CRO.
  • A key leadership role with the mandate and resources to build a new pharmacology capability from the ground up.
  • Close collaboration with expert teams in structural biology, biophysics, medicinal chemistry, and computational chemistry.
  • Competitive remuneration package and opportunities for professional development.
  • A dynamic, international, and scientifically driven team based in the Greater Munich area.

Contact Details

Proteros biostructures GmbH People Team Bunsenstr. 7a, 82152 Martinsried +49 89 700761 0 [email protected]

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